Biomedical Sciences

Volume 1, Issue 1, May 2015

  • Beta-hydroxy-beta-methylbutyrate Inhibits Lipopolysaccharide-induced Interleukin-6 Expression by Increasing Protein Phosphatase-1α Expression

    Mitsutaka Yakabe, Sumito Ogawa, Hidetaka Ota, Katsuya Iijima, Masato Eto, Yasuyoshi Ouchi, Masahiro Akishita

    Issue: Volume 1, Issue 1, May 2015
    Pages: 1-5
    Received: May 15, 2015
    Accepted: May 25, 2015
    Published: May 26, 2015
    DOI: 10.11648/j.bs.20150101.11
    Downloads:
    Views:
    Abstract: Beta-hydroxy-beta-methylbutyrate (HMB), a leucine metabolite, has been suggested to inhibit inflammation. However, its mechanism is not fully understood. Here we show that HMB repressed LPS-induced interleukin-6 (IL-6) expression by inhibiting the NF-B and AP-1 pathways. When protein phosphatase-1 (PP1) was knocked down, the effects of HMB were ... Show More
  • PGC-1α, A Stimuli-Inducible Nuclear Receptor Coactivator: Structural Features and Role in Skeletal Muscle Metabolism Gene Regulation

    Yasutomi Kamei, Yukino Hatazawa, Ryoji Yoshimura, Shinji Miura

    Issue: Volume 1, Issue 1, May 2015
    Pages: 6-9
    Received: Jun. 09, 2015
    Accepted: Jun. 19, 2015
    Published: Jun. 23, 2015
    DOI: 10.11648/j.bs.20150101.12
    Downloads:
    Views:
    Abstract: PGC-1α was initially identified as a PPARγ-interacting protein from the brown adipose tissue and was subsequently found to associate with many nuclear receptors and transcription factors. Among many coactivators of nuclear receptors, PGC-1α is unique because of its induced expression by stimuli, such as cold stress in the brown adipose tissue, fast... Show More