Volume 5, Issue 4, December 2019, Page: 67-70
Platelet Parameters and Variations With Age Amongst Elderly Nepalese Presenting in BPKIHS, Dharan Research Project (March 29-April 25)
Indira Ojha, Department of Pathology, BP Koirala Institute of Health Sciences, Dharan, Nepal
Seema Oli, Department of Pathology, BP Koirala Institute of Health Sciences, Dharan, Nepal
Received: Jun. 21, 2019;       Accepted: Jul. 18, 2019;       Published: Nov. 25, 2019
DOI: 10.11648/j.bs.20190504.15      View  500      Downloads  83
Platelets are derived from megakaryocytes and help in hemostasis and produce growth factors. Platelet count and MPV are parameters used in various conditions and vary with age and sex. The purpose of this study was to compare platelet count and MPV of healthy young with healthy elderly and calculate normal range of platelet count and to find relationship of platelet count and MPV with age and sex. Prospective study was done on 202 people visiting hematology department of BPKIHS, 100 as cases and 102 as controls, after obtaining ethical clearance. Only the consenting individuals and individual meeting inclusion criteria were included in the study. Blood sample was drawn in EDTA vial and Platelet counts and MPV was measured by 5 part hematology analyzer. Results showed that platelet count is higher in females and young individuals while platelet volume is higher in elderly. Study shows that there is insignificant difference between platelet count and MPV between elderly population and young control. Thus, from this prospective study conducted on 202 people we concluded that there is a rise in MPV with age and decrease in platelet count. However, the difference is insignificant and does not mandate separate reference range for various age groups.
Platelets, Platelet Count, Mean Platelet Volume
To cite this article
Indira Ojha, Seema Oli, Platelet Parameters and Variations With Age Amongst Elderly Nepalese Presenting in BPKIHS, Dharan Research Project (March 29-April 25), Biomedical Sciences. Vol. 5, No. 4, 2019, pp. 67-70. doi: 10.11648/j.bs.20190504.15
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mariza, D. S., Claria, H. A., Schivanke, M. B., Clarice L., Irana, M. C. (2007). Haematological and nutritional parameters in apparently healthy elderly individuals. Revista Brasleira Hematologia e Hemoterapia 29 (2): 10.
Madimir, M. D. (1981). Diseases of Ageing. John Wright PSG Inc. London. Giles, C. (2008). Platelet count and mean platelet volume. British Journal of Haematology, 48 (1): 31-37.
Bath, P. M., Butterworth R. J. (1996). Platelet size: measurement, physiology and vascular disease. Blood Coagulation and Fibrinolysis, Vol. 7 (2); 152-161.
Butkiewicz AM, Kemona H, Dymicka-Piekarska V, Matowicka-Karna J, Radziwon P, Lipska A (2006): Platelet count, mean platelet volume and thrombopoietic indices in healthy women and men. Thrombosis Res, 118: 199-204.
Bernd, van der Loo, John, F. M. (1999). A Role for Changes in Platelet Production in the Cause of Acute Coronary Syndromes. Arteriosclerosis, Thrombosis, and Vascular Biology, 19: 672-679.
Wu, Yang Yang et al (2019) Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study. BMC Cancer 19: 314.
Aleksandra Korniluk et al (2019) Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Hindawi Mediators of Inflammation, Article ID 9213074, 14 pages.
BHATTA, Sushama et al. (2019) Mean Platelet Volume and Platelet Count in Patients with Type 2 Diabetes Mellitus and Impaired Fasting Glucose. Journal of Nepal Health Research Council, [S. l.], v. 16, n. 41, p. 392-395. ISSN 1999-6217.
Martin, J. F., Plumb, J., Kilbey, R. S., Kishk, Y. T. (1983). Changes in volume and density of platelets in myocardial infarction. British Medical Journal, 287: 456-459.
Kemona H, Prokopanicz J, Wolosanicz N (1977): The count of blood platelets and sex in humans. Cell Mol Life Sci, 34: 257.
Toryila, J. E., Amadi, K., & Adelaiye, A. B (2009). Platelet Counts And Mean Platelet Volume Amongst Elderly Nigerians Science World Journal 4 (1): 1597-6343.
Ginevra Biino, Carlo L. Balduini, Laura Casula, Piergiorgio Cavallo, Simona Vaccargiu, Debora Parracciani, Donatella Serra, Laura Portas, Federico Murgia, and Mario Pirastu(2011): Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits, Haematologica.
Rowan McIlhagger1, Alan J Gow2,3, Caroline E Brett3, Janie Corley 3, Michelle Taylor3, Ian J Deary2,3 and John M Starr (2010): Differences in the haematological profile of healthy 70 year old men and women: normal ranges with confirmatory factor analysis, BMC Blood Disorders, 10: 4
Okeke P. U. (2012): Platelet Count and Indices of Mean Platelet Volume, Platelet Distribution Width and Platelet Large Cell Ratio - Is there any Sex Difference?; 17, 978-3-656-16529-3.
Brahimi, S., Arabi, A., Touhami, H., Seghier, F., Kubisz, P., Cronberg, S. (1984). Platelet count and mean platelet volume in an Angerian population indicating a new prevalence of mediterran macrothrombocytopenia. Human Hered., 34: 396-398.
Browse journals by subject